To understand if the cause of the recurrent miscarriages is genetic, both parent’s will have their chromosomes mapped in a process known as karyotyping. This will determine if there are any abnormalities within the chromosomes that could be the cause of contributing to the
Our Hong Kong facility is capable of performing multiple genetic tests for at-risk couples or couples who are experiencing recurrent miscarriages. The test includes 2 parts:
Karyotyping: the gold standard method for detecting chromosomal disorders.
Cytogenetics can detect numerical abnormalities and all structural abnormalities of size larger than 15Mb (Fig. 2a & 2b).
Array-based Comparative Genomic Hybridization(aCGH): covers small-sized structural abnormalities, could serve the purpose of detecting copy number variants (CNVs) such as deletions and insertions with a 10-fold increased resolution compared with karyotyping
By combining the Karyotyping test and the microarray analysis, we can achieve a complete genetic map that will determine comprehensively if there is a chromosomal factor involved in the recurrent miscarriages.